Designer crystals for drug advancements

Close up of the metal organic framework crystals

Close up of the metal organic framework crystals

A breakthrough in chemistry led by Australian scientists could revolutionise healthcare by fast-tracking the development of vaccines and tiny devices that give real-time information about a patient’s condition.

Collaborating with teams in Japan, Austria, Monash University and The University of Adelaide, CSIRO scientists led by Dr Paolo Falcaro have found a way to harness the potential of designer crystals known as Metallic Organic Frameworks (MOFs) – the most porous materials on the planet.

MOFs have so many holes inside that a single teaspoon of the powdery material has the same surface area as a football field.

Since their discovery in 1999, they have been used in an array of fields including pharmaceutics, electronics and horticulture.

Although the novel materials exert a powerful appeal for scientists, one of the roadblocks to realising the full potential of MOFs is their erratic structure, which makes it difficult to integrate them into functional devices.

“We’ve found a way to control the structure of MOFs and align them in one direction, creating a MOF film,” CSIRO scientist Dr Aaron Thornton, co-author of the paper published today in  Nature Materials  said.

“Having the MOFs in alignment means they conduct a current far better, opening up more electrical uses such as implantable medical devices that give real-time information about someone’s health.

“It also gives researchers more control in the development of vaccines, which will fast-track the process.

“MOFs could also be structured in such a way that they’d only react with certain compounds or elements – for example, miners could wear clothes impregnated with a layer of MOFs that tell them when dangerous gases are building up.

“The possibilities are endless.”

Once the hard work was complete the scientists had to prove that the MOFs were in alignment.

This was achieved by placing a polarisable fluorescent molecule in aligned MOFs.

If the MOFs were all in perfect alignment then they would only be able to make them light up along the one axis, in line with the MOFs so you could turn the light on or off by rotating the film.

CSIRO has already used MOFs to develop a  molecular shell to protect and deliver drugs and vaccines, a ‘solar sponge’ that can capture and release carbon dioxide emissions and  plastic material that gets better with age.

Find out how we’ve been applying these clever MOF crystals to other industries, including potential opportunities for your business –  HERE

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